000154132 001__ 154132
000154132 005__ 20190316234928.0
000154132 020__ $$a978-1-4244-7905-4
000154132 037__ $$aCONF
000154132 245__ $$aP450-mediated electrochemical sensing of drugs in human plasma for personalized therapy
000154132 269__ $$a2010
000154132 260__ $$c2010
000154132 336__ $$aConference Papers
000154132 520__ $$aNowadays, the concept of personalized therapy gains momentum. Pharmacogenomics, which represents a first answer to these needs, has the drawback of neglecting some variations of therapy response due to non-genetic factors. The aim of this paper is to investigate the feasibility of a non-genetic approach to personalized therapy, via the point-of-care drug monitoring in biological fluids with electrochemical biosensors. The proposed biosensor is based on the use of P450 enzymes as probe molecules, thanks to their key role in human metabolism. Multiwalled carbon nanotubes are used to enhance biosensor sensitivity. Results show how the proposed system is capable to detect drug amounts within the corresponding pharmacological ranges in human serum.
000154132 6531_ $$aP450
000154132 6531_ $$apersonalized therapy
000154132 6531_ $$aelectrochemistry
000154132 6531_ $$ahuman serum
000154132 700__ $$0242421$$g176841$$aCavallini, Andrea
000154132 700__ $$0242413$$g182237$$aCarrara, Sandro
000154132 700__ $$g167918$$aDe Micheli, Giovanni$$0240269
000154132 700__ $$aErokhin, V.
000154132 7112_ $$dJuly 18-21, 2010$$cBerlin, Germany$$a6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME)
000154132 773__ $$tProceedings of the 6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME)$$q1-4
000154132 8564_ $$uhttps://infoscience.epfl.ch/record/154132/files/P450%20-%20PRIME%202010%20-%20P450_Cavallini_.pdf$$zn/a$$s801021$$yn/a
000154132 909C0 $$xU11140$$0252283$$pLSI1
000154132 909CO $$pIC$$qGLOBAL_SET$$ooai:infoscience.tind.io:154132$$pconf$$pSTI
000154132 917Z8 $$x176271
000154132 917Z8 $$x112915
000154132 937__ $$aEPFL-CONF-154132
000154132 973__ $$rNON-REVIEWED$$sPUBLISHED$$aEPFL
000154132 980__ $$aCONF