000151746 001__ 151746
000151746 005__ 20180913055927.0
000151746 022__ $$a0036-8075
000151746 02470 $$2PMID$$a10731134
000151746 02470 $$2ISI$$a000086049100035
000151746 0247_ $$2doi$$a10.1126/science.287.5461.2204
000151746 037__ $$aARTICLE
000151746 245__ $$aComparative genomics of the eukaryotes
000151746 269__ $$a2000
000151746 260__ $$bAmerican Association for the Advancement of Science$$c2000
000151746 336__ $$aJournal Articles
000151746 520__ $$aA comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
000151746 6531_ $$aGenome
000151746 6531_ $$aProteome
000151746 700__ $$aRubin, G. M.
000151746 700__ $$aYandell, M. D.
000151746 700__ $$aWortman, J. R.
000151746 700__ $$aGabor Miklos, G. L.
000151746 700__ $$aNelson, C. R.
000151746 700__ $$aHariharan, I. K.
000151746 700__ $$aFortini, M. E.
000151746 700__ $$aLi, P. W.
000151746 700__ $$aApweiler, R.
000151746 700__ $$aFleischmann, W.
000151746 700__ $$aCherry, J. M.
000151746 700__ $$aHenikoff, S.
000151746 700__ $$aSkupski, M. P.
000151746 700__ $$aMisra, S.
000151746 700__ $$aAshburner, M.
000151746 700__ $$aBirney, E.
000151746 700__ $$aBoguski, M. S.
000151746 700__ $$aBrody, T.
000151746 700__ $$aBrokstein, P.
000151746 700__ $$aCelniker, S. E.
000151746 700__ $$aChervitz, S. A.
000151746 700__ $$aCoates, D.
000151746 700__ $$aCravchik, A.
000151746 700__ $$aGabrielian, A.
000151746 700__ $$aGalle, R. F.
000151746 700__ $$aGelbart, W. M.
000151746 700__ $$aGeorge, R. A.
000151746 700__ $$aGoldstein, L. S.
000151746 700__ $$aGong, F.
000151746 700__ $$aGuan, P.
000151746 700__ $$aHarris, N. L.
000151746 700__ $$aHay, B. A.
000151746 700__ $$aHoskins, R. A.
000151746 700__ $$aLi, J.
000151746 700__ $$aLi, Z.
000151746 700__ $$aHynes, R. O.
000151746 700__ $$aJones, S. J.
000151746 700__ $$aKuehl, P. M.
000151746 700__ $$0244384$$aLemaitre, B.$$g178546
000151746 700__ $$aLittleton, J. T.
000151746 700__ $$aMorrison, D. K.
000151746 700__ $$aMungall, C.
000151746 700__ $$aO'Farrell, P. H.
000151746 700__ $$aPickeral, O. K.
000151746 700__ $$aShue, C.
000151746 700__ $$aVosshall, L. B.
000151746 700__ $$aZhang, J.
000151746 700__ $$aZhao, Q.
000151746 700__ $$aZheng, X. H.
000151746 700__ $$aLewis, S.
000151746 773__ $$j287$$k5461$$q2204-15$$tScience (New York, N.Y.)
000151746 8564_ $$s9629288$$uhttps://infoscience.epfl.ch/record/151746/files/Science-2000-Rubin-2204-15_.pdf$$yPublisher's version$$zPublisher's version
000151746 909C0 $$0252304$$pUPLEM$$xU11772
000151746 909CO $$ooai:infoscience.tind.io:151746$$pSV$$particle
000151746 917Z8 $$x182396
000151746 937__ $$aEPFL-ARTICLE-151746
000151746 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000151746 980__ $$aARTICLE