000151413 001__ 151413
000151413 005__ 20180913055918.0
000151413 022__ $$a1528-2511
000151413 02470 $$2PMID$$a9949807
000151413 037__ $$aARTICLE
000151413 245__ $$aAnalysis of the genome of Mycobacterium tuberculosis H37Rv
000151413 269__ $$a1999
000151413 260__ $$c1999
000151413 336__ $$aReviews
000151413 520__ $$aThe powerful combination of genomics and bioinformatics is providing a wealth of information about Mycobacterium tuberculosis, the aetiological agent of human tuberculosis, that will facilitate the conception and development of new therapies. The starting point for genome sequencing was the integrated map of the 4.4 Mb circular chromosome of the widely used, virulent reference strain, M. tuberculosis H37Rv. Cosmids and bacterial artificial chromosomes were selected from ordered libraries and subjected to systematic shotgun sequence analysis. This approach simplified sequence assembly as the genome is rich in repetitive DNA. In common with most bacteria, > 90% of the potential coding capacity is used, and probable or tentative functions could be attributed to > 70% of the genes. The potential biological roles of two of the principal driving forces in genome dynamics, insertion sequence elements and polymorphic multigene families are discussed.
000151413 6531_ $$aGenome, Bacterial
000151413 700__ $$0243892$$aCole, S T$$g177247
000151413 700__ $$aBarrell, B G
000151413 773__ $$j217$$q160-72; discussion 172-7$$tNovartis Foundation symposium
000151413 909C0 $$0252302$$pUPCOL$$xU11742
000151413 909CO $$ooai:infoscience.tind.io:151413$$pSV$$preview
000151413 937__ $$aEPFL-REVIEW-151413
000151413 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000151413 980__ $$aREVIEW