000151408 001__ 151408
000151408 005__ 20180913055918.0
000151408 022__ $$a1438-4221
000151408 02470 $$2PMID$$a11045919
000151408 037__ $$aARTICLE
000151408 245__ $$aComparative genomics of the mycobacteria
000151408 269__ $$a2000
000151408 260__ $$c2000
000151408 336__ $$aReviews
000151408 520__ $$aThe genus mycobacteria includes two important human pathogens Mycobacterium tuberculosis and Mycobacterium lepra. The former is reputed to have the highest annual global mortality of all pathogens. Their slow growth, virulence for humans and particular physiology makes these organisms extremely difficult to work with. However the rapid development of mycobacterial genomics following the completion of the Mycobacterium tuberculosis genome sequence provides the basis for a powerful new approach for the understanding of these organisms. Five further genome sequencing projects of closely related mycobacterial species with differing host range, virulence for humans and physiology are underway. A comparative genomic analysis of these species has the potential to define the genetic basis of these phenotypes which will be invaluable for the development of urgently needed new vaccines and drugs. This minireview summarises the different techniques that have been employed to compare these genomes and gives an overview of the wealth of data that has already been generated by mycobacterial comparative genomics.
000151408 6531_ $$aGenome, Bacterial
000151408 700__ $$aBrosch, R
000151408 700__ $$aGordon, S V
000151408 700__ $$aPym, A
000151408 700__ $$aEiglmeier, K
000151408 700__ $$aGarnier, T
000151408 700__ $$g177247$$aCole, S T$$0243892
000151408 773__ $$j290$$tInternational journal of medical microbiology : IJMM$$k2$$q143-52
000151408 909C0 $$xU11742$$0252302$$pUPCOL
000151408 909CO $$pSV$$preview$$ooai:infoscience.tind.io:151408
000151408 937__ $$aEPFL-REVIEW-151408
000151408 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000151408 980__ $$aREVIEW