000151331 001__ 151331
000151331 005__ 20181203021959.0
000151331 022__ $$a0923-2508
000151331 02470 $$2PMID$$a1488556
000151331 0247_ $$2doi$$a10.1016/0923-2508(92)90067-X
000151331 037__ $$aARTICLE
000151331 245__ $$aIsolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum
000151331 269__ $$a1992
000151331 260__ $$c1992
000151331 336__ $$aJournal Articles
000151331 520__ $$aINH-resistant mutants of Mycobacterium aurum and M. smegmatis were isolated and characterized in an attempt to provide fresh insight into the activity of isoniazid (INH), a key antibiotic in the treatment of tuberculosis. In both cases, high levels of resistance were accompanied by slower growth rate, by loss of peroxidase and reduced catalase activities, although mycolic acid production was unaffected. A gene homologous to the katG gene of M. tuberculosis, encoding peroxidase-catalase, was detected in wild-type and INH-resistant strains and it appears that INH resistance may stem from the loss of its product.
000151331 700__ $$aHeym, B
000151331 700__ $$g177247$$aCole, S T$$0243892
000151331 773__ $$j143$$tResearch in microbiology$$k7$$q721-30
000151331 909C0 $$xU11742$$0252302$$pUPCOL
000151331 909CO $$pSV$$particle$$ooai:infoscience.tind.io:151331
000151331 937__ $$aEPFL-ARTICLE-151331
000151331 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000151331 980__ $$aARTICLE