000151328 001__ 151328
000151328 005__ 20181203021959.0
000151328 022__ $$a0066-4804
000151328 02470 $$2PMID$$a8460911
000151328 037__ $$aARTICLE
000151328 245__ $$aMolecular basis of rifampin resistance in Mycobacterium leprae.
000151328 269__ $$a1993
000151328 260__ $$c1993
000151328 336__ $$aJournal Articles
000151328 520__ $$aRifampin is currently the most potent drug used in leprosy control programs. We show that the rifampin resistance which emerged in nine patients with lepromatous leprosy, who had received rifampin monotherapy, stemmed from mutations in the rpoB gene, which encodes the beta subunit of RNA polymerase of Mycobacterium leprae. In eight cases missense mutations were found to affect a serine residue, Ser-425, while in the remaining mutant a small insertion was found close to this site. These findings will be of use for the development of a rapid screening procedure, involving the polymerase chain reaction, for monitoring the emergence of rifampin-resistant M. leprae strains.
000151328 700__ $$aHonore, N
000151328 700__ $$0243892$$aCole, S T$$g177247
000151328 773__ $$j37$$k3$$q414-8$$tAntimicrobial agents and chemotherapy
000151328 909C0 $$0252302$$pUPCOL$$xU11742
000151328 909CO $$ooai:infoscience.tind.io:151328$$pSV$$particle
000151328 937__ $$aEPFL-ARTICLE-151328
000151328 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000151328 980__ $$aARTICLE