000151327 001__ 151327
000151327 005__ 20181203021959.0
000151327 022__ $$a0021-9193
000151327 02470 $$2PMID$$a8320241
000151327 037__ $$aARTICLE
000151327 245__ $$aCharacterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.
000151327 269__ $$a1993
000151327 260__ $$c1993
000151327 336__ $$aJournal Articles
000151327 520__ $$aThe isoniazid susceptibility of Mycobacterium tuberculosis is mediated by the product of the katG gene which encodes the heme-containing enzyme catalase-peroxidase. In this study, the chromosomal location of katG has been established and its nucleotide sequence has been determined so that the primary structure of catalase-peroxidase could be predicted. The M. tuberculosis enzyme is an 80,000-dalton protein containing several motifs characteristic of peroxidases and shows strong similarity to other bacterial catalase-peroxidases. Expression of the katG gene in M. tuberculosis, M. smegmatis, and Escherichia coli was demonstrated by Western blotting (immunoblotting). Homologous genes were detected in other mycobacteria, even those which are naturally insensitive to isoniazid.
000151327 6531_ $$aBacterial Proteins
000151327 700__ $$aHeym, B
000151327 700__ $$aZhang, Y
000151327 700__ $$aPoulet, S
000151327 700__ $$aYoung, D
000151327 700__ $$g177247$$aCole, S T$$0243892
000151327 773__ $$j175$$tJournal of bacteriology$$k13$$q4255-9
000151327 909C0 $$xU11742$$0252302$$pUPCOL
000151327 909CO $$pSV$$particle$$ooai:infoscience.tind.io:151327
000151327 937__ $$aEPFL-ARTICLE-151327
000151327 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000151327 980__ $$aARTICLE