Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis.
Molecular characterization of a streptomycin-dependent mutant of Mycobacterium tuberculosis revealed the presence of a novel mutation in the rrs gene encoding 16S rRNA. Insertion of an additional cytosine in the 530 loop of 16S rRNA, a region known to be involved in streptomycin susceptibility and resistance, was associated with streptomycin dependence.
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Record created on 2010-09-07, modified on 2016-08-08