000151254 001__ 151254
000151254 005__ 20181203021958.0
000151254 0247_ $$2doi$$a10.1016/S0035-9203(02)90222-1
000151254 022__ $$a0035-9203
000151254 02470 $$2PMID$$a11925980
000151254 037__ $$aARTICLE
000151254 245__ $$aMycobacterial genomics
000151254 260__ $$c2002
000151254 269__ $$a2002
000151254 336__ $$aJournal Articles
000151254 500__ $$aRoyal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health.
000151254 520__ $$aThe small size of their genomes made bacterial ideal model organisms for the emerging field of genomics. Elucidating the genome sequences of mycobacteria was particularly attractive owing to the difficulties inherent in their manipulation. The slow growth rate, clumping, and requirement for category III containment make manipulation of Mycobacterium tuberculosis-complex strains laborious. M. leprae presents even greater problems as it has resisted all attempts at axenic culture. Availability of genome sequence data promised to accelerate our knowledge of the fundamental biology of these organisms, and to offer clues to the basis for their virulence, tropism and persistence in the host. This article will focus on what the genome sequences of M. tuberculosis and M. leprae have taught us about these pathogens, and how comparative genomics has exposed some of the fundamental differences between the species.
000151254 6531_ $$aGenome
000151254 6531_ $$aBacterial
000151254 700__ $$aGordon, Stephen V
000151254 700__ $$aBrosch, Roland
000151254 700__ $$aEiglmeier, Karin
000151254 700__ $$aGarnier, Thierry
000151254 700__ $$aHewinson, R Glyn
000151254 700__ $$g177247$$aCole, Stewart T$$0243892
000151254 773__ $$j96$$tTransactions of the Royal Society of Tropical Medicine and Hygiene$$k1$$q1-6
000151254 909C0 $$xU11742$$0252302$$pUPCOL
000151254 909CO $$pSV$$particle$$ooai:infoscience.tind.io:151254
000151254 917Z8 $$x148230
000151254 917Z8 $$x148230
000151254 937__ $$aEPFL-ARTICLE-151254
000151254 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000151254 980__ $$aARTICLE