000151209 001__ 151209
000151209 005__ 20181203021957.0
000151209 022__ $$a1462-5814
000151209 02470 $$2PMID$$a16939536
000151209 0247_ $$2doi$$a10.1111/j.1462-5822.2006.00790.x
000151209 037__ $$aARTICLE
000151209 245__ $$aEarly trafficking events of Mycobacterium ulcerans within Naucoris cimicoides
000151209 269__ $$a2006
000151209 260__ $$c2006
000151209 336__ $$aJournal Articles
000151209 520__ $$aThe severe skin-destructive disease caused by Mycobacterium ulcerans, named Buruli ulcer, is the third most important mycobacterial disease in humans after tuberculosis and leprosy. Recently we demonstrated that M. ulcerans could colonize the salivary glands of the water bug, Naucoris cimicoides. In this study, we report that M. ulcerans may be delivered from the digested prey aspirate to the coelomic cavity via a unique headspace, the head capsule (HC). During the infected meal, we observed that M. ulcerans clusters adhered to the stylets that were retracted in the HC at the end of the meal. M. ulcerans was able to translocate from the HC to the coelomic cavity where it is phagocytosed by the plasmatocytes. These cells are subverted as shuttle cells and deliver M. ulcerans to the salivary glands. At this early stage of its parasitic life style, two other important features of M. ulcerans can be documented: first, mycolactone is not required for translocation of M. ulcerans into the HC, in contrast to the next step, colonization of the salivary glands; second, M. ulcerans clusters bind a member of the serpin protein family present in the salivary gland homogenate.
000151209 700__ $$aMarsollier, Laurent
000151209 700__ $$aAndré, Jean-Paul S
000151209 700__ $$aFrigui, Wafa
000151209 700__ $$aReysset, Gilles
000151209 700__ $$aMilon, Geneviève
000151209 700__ $$aCarbonnelle, Bernard
000151209 700__ $$aAubry, Jacques
000151209 700__ $$g177247$$aCole, Stewart T$$0243892
000151209 773__ $$j9$$tCellular microbiology$$k2$$q347-55
000151209 909C0 $$xU11742$$0252302$$pUPCOL
000151209 909CO $$pSV$$particle$$ooai:infoscience.tind.io:151209
000151209 937__ $$aEPFL-ARTICLE-151209
000151209 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000151209 980__ $$aARTICLE