Can bioactivity be tested in vitro with SBF solution ?
A large part of the scientiﬁc community has accepted the paradigm that a simulated body solution (SBF) can be used to test the bioactivity of a material. This is exempliﬁed by the rapidly increasing number of publications using this test. The aim of this document is to demonstrate that (i) there is presently not enough scientiﬁc data to support this assumption, and(ii) even though the assumption was valid, the way the test is generally conducted leaves room for improvement. Theoretical arguments and facts supporting these statements are provided, together with possible improvements of the proposed bioactivity test.
Keywords: Bone ; Bioactivity ; Calcium phosphate ; Bioglass ; Hydroxyapatite ; Simulate body fluid ; Beta-Tricalcium Phosphate ; Simulated Body-Fluid ; Sol-Gel Glass ; Hydroxyapatite ; Resorption ; Apatite ; Serum ; Vivo ; Precipitation ; Bioglass((R))
Record created on 2010-08-17, modified on 2016-08-08