000150236 001__ 150236
000150236 005__ 20180913055839.0
000150236 0247_ $$2doi$$a10.1016/j.biomaterials.2010.02.021
000150236 022__ $$a0142-9612
000150236 02470 $$2ISI$$a000277899500001
000150236 037__ $$aARTICLE
000150236 245__ $$aIn vivo study of an injectable poly(acrylonitrile)-based hydrogel paste as a bulking agent for the treatment of urinary incontinence
000150236 269__ $$a2010
000150236 260__ $$bElsevier$$c2010
000150236 336__ $$aJournal Articles
000150236 520__ $$aUrinary incontinence can be treated by endoscopic injection of bulking agents, however, no optimal therapeutic effect has been achieved upon this treatment yet. In the present study, the development of a injectable poly(acrylonitrile) hydrogel paste is described, and its efficacy and histological behavior, once injected into the submucosal space of the minipig bladder, are evaluated. A device was developed to mix poly(acrylonitrile) hydrogel powder with glycerin, used as carrier, prior to injection into the submucosal space of the bladder. Several paste deposits, depending on the size of the bladder, were injected per animal. The implants were harvested at days 7, 14, 21, 28, 84 and 168 and analyzed morphologically and by histology. The persistence of the implants was demonstrated. However, at later time points the implants were split up and surrounded by granulomatous tissue, which was gradually replaced by histiocytes and adipocytes. Transitory focal urothelial metaplasia was observed only at day 7 and moderate foreign body reaction  was detected predominantly between the second and fifth week. This study demonstrated the feasibility to develop an injectable paste of poly(acrylonitrile) hydrogel thought to provide the expected bulking effect, necessary for the treatment of urinary incontinence.
000150236 6531_ $$aPolyacrylonitrile
000150236 6531_ $$aHydrogel
000150236 6531_ $$aSwelling
000150236 6531_ $$aUrinary tract
000150236 6531_ $$aBladder
000150236 700__ $$aRamseyer, Pascal
000150236 700__ $$aMicol, Lionel A.
000150236 700__ $$aEngelhardt, Eva-Maria
000150236 700__ $$aOsterheld, Maria-Chiara
000150236 700__ $$0240350$$aHubbell, Jeffrey A.$$g141360
000150236 700__ $$aFrey, Peter
000150236 773__ $$j31$$k17$$q4613-4619$$tBiomaterials
000150236 909C0 $$0252196$$pLMRP$$xU11032
000150236 909CO $$ooai:infoscience.tind.io:150236$$particle
000150236 917Z8 $$x138841
000150236 937__ $$aEPFL-ARTICLE-150236
000150236 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000150236 980__ $$aARTICLE