Receptors of anthrax toxin and cell entry
Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed.
Keywords: Anthrax toxin ; Receptors ; Endocytosis ; Lrp6 ; Arap3 ; Capillary Morphogenesis Protein-2 ; Protective Antigen ; Lethal Factor ; Tumor Endothelium ; Crystal-Structure ; Edema Toxin ; Rho Gtpases ; Binding ; Domain ; Arap3
Record created on 2010-07-29, modified on 2016-10-07