Receptors of anthrax toxin and cell entry

Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed.


Published in:
Molecular aspects of medicine, 30, 6, 406-12
Year:
2009
Publisher:
Elsevier
ISSN:
1872-9452
Keywords:
Laboratories:




 Record created 2010-07-29, last modified 2018-09-13


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