000150118 001__ 150118
000150118 005__ 20190316234828.0
000150118 022__ $$a1095-564X
000150118 02470 $$2ISI$$a000277404300013
000150118 0247_ $$2doi$$a10.1016/j.ydbio.2010.03.006
000150118 037__ $$aARTICLE
000150118 245__ $$aAdditive and global functions of HoxA cluster genes in mesoderm derivatives
000150118 269__ $$a2010
000150118 260__ $$bElsevier$$c2010
000150118 336__ $$aJournal Articles
000150118 520__ $$aHox genes encode transcription factors that play a central role in the specification of regional identities along the anterior to posterior body axis. In the developing mouse embryo, Hox genes from all four genomic clusters are involved in range of developmental processes, including the patterning of skeletal structures and the formation of several organs. However, the functional redundancy observed either between paralogous genes, or among neighboring genes from the same cluster, has hampered functional analyses, in particular when synergistic, cluster-specific functions are considered. Here, we report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations. Likewise, mild phenotypes are observed in both appendicular and axial skeleton. However, a striking effect was uncovered in the hematopoietic system, much stronger than that seen for Hoxa9 inactivation alone, which involves stem cells (HSCs) as well as the erythroid lineage, indicating that several Hoxa genes are necessary for normal hematopoiesis to occur. Finally, the combined deletions of Hoxa and Hoxd genes reveal abnormalities in axial elongation as well as skin morphogenesis that are likely the results of defects in epithelial-mesenchymal interactions.
000150118 6531_ $$aHoxA
000150118 6531_ $$aHoxD
000150118 6531_ $$aMesoderm
000150118 6531_ $$aHematopoiesis
000150118 6531_ $$aSkeleton
000150118 6531_ $$aOrgans
000150118 6531_ $$aSkin
000150118 6531_ $$aHematopoietic Stem-Cells
000150118 6531_ $$aHomeobox Genes
000150118 6531_ $$aMutant Mice
000150118 6531_ $$aHomeotic Transformations
000150118 6531_ $$aTargeted Disruptions
000150118 6531_ $$aMyeloid-Leukemia
000150118 6531_ $$aLimb Development
000150118 6531_ $$aAxial Skeleton
000150118 6531_ $$aNervous-System
000150118 6531_ $$aBody Plan
000150118 700__ $$aDi-Poï, Nicolas
000150118 700__ $$0240232$$g181960$$aKoch, Ute
000150118 700__ $$0240231$$g172749$$aRadtke, Freddy
000150118 700__ $$aDuboule, Denis$$g141236$$0240276
000150118 773__ $$j341$$tDevelopmental biology$$k2$$q488-98
000150118 8564_ $$uhttps://infoscience.epfl.ch/record/150118/files/Additive%20and%20global%20functions_Di-Poi.pdf$$zn/a$$s6919943$$yPublisher's version
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000150118 909C0 $$pUPRAD$$xU11429$$0252086
000150118 909CO $$qGLOBAL_SET$$pSV$$particle$$ooai:infoscience.tind.io:150118
000150118 917Z8 $$x177499
000150118 937__ $$aEPFL-ARTICLE-150118
000150118 973__ $$rNON-REVIEWED$$sPUBLISHED$$aEPFL
000150118 980__ $$aARTICLE