000150117 001__ 150117
000150117 005__ 20190316234828.0
000150117 022__ $$a1878-1551
000150117 02470 $$2ISI$$a000277105800006
000150117 0247_ $$2doi$$a10.1016/j.devcel.2010.04.002
000150117 037__ $$aARTICLE
000150117 245__ $$aThe origin of digits: expression patterns versus regulatory mechanisms
000150117 269__ $$a2010
000150117 260__ $$bElsevier$$c2010
000150117 336__ $$aJournal Articles
000150117 520__ $$aIn the emerging discipline of Evo-Devo, the analysis of gene expression patterns can be deceptive without a clear understanding of the underlying regulatory strategies. Here, we use the paradigm of hand and foot evolution to argue that the consideration of the regulatory mechanisms controlling developmental gene expression is essential to resolve comparative conundrums. In this context, we discuss the adaptive relevance of evolving stepwise, distinct developmental regulatory mechanisms to build an arm, i.e., a composite structure with functional coherence.
000150117 6531_ $$aGene Expression Profiling
000150117 700__ $$aWoltering, Joost M.
000150117 700__ $$0240276$$aDuboule, Denis$$g141236
000150117 773__ $$j18$$k4$$q526-32$$tDevelopmental cell
000150117 8564_ $$s445923$$uhttps://infoscience.epfl.ch/record/150117/files/The%20origin%20of%20digits_Woltering.pdf$$yPublisher's version$$zn/a
000150117 909C0 $$0252099$$pUPDUB$$xU11705
000150117 909CO $$ooai:infoscience.tind.io:150117$$pSV$$particle$$qGLOBAL_SET
000150117 917Z8 $$x177499
000150117 937__ $$aEPFL-ARTICLE-150117
000150117 973__ $$aEPFL$$rNON-REVIEWED$$sPUBLISHED
000150117 980__ $$aARTICLE