000148607 001__ 148607
000148607 005__ 20181203021857.0
000148607 0247_ $$2doi$$a10.1002/etc.221
000148607 022__ $$a0730-7268
000148607 02470 $$2ISI$$a000280481200001
000148607 037__ $$aARTICLE
000148607 245__ $$aOccurrence and fate of micropollutants in the Vidy Bay of  Lake Geneva, part I: Priority list for environmental risk assessment of  pharmaceuticals
000148607 269__ $$a2010
000148607 260__ $$bSociety of Environmental Toxicology and Chemistry Press$$c2010
000148607 336__ $$aJournal Articles
000148607 520__ $$aAbstract—Pharmaceuticals are substances designed to have a biological effect in humans. Their presence in the environment, especially in surface waters, is of increasing concern because of their potential risk to non-target species. A large number of pharmaceuticals are on the market; for example, approximately 2,000 active ingredients are approved in Europe, and many of them have already been detected in surface water. It is therefore crucial to select the substances that may do the most harm to the environment prior to performing measurements and extensive risk assessment. In the present study, a method to determine a list of pharmaceuticals to survey in surface water is proposed. Inclusion of substances on the list was based on a screening procedure, the analytical feasibility, and previous knowledge of pharmaceuticals detected in water. The screening procedure proposed here is an improvement on the standard procedure of the European Medicine Evaluation Agency (EMEA). It is designed to decrease the number of pharmaceuticals to be evaluated in a stepwise manner, thus decreasing the number of data necessary for the evaluation. We applied our approach to determine a list of 37 pharmaceuticals and four hormones to survey in a specific region of Switzerland, the Lake Geneva area, and discussed the advantages and weak points of the method.
000148607 6531_ $$aPharmaceuticals
000148607 6531_ $$aScreening procedure
000148607 6531_ $$aPriority list
000148607 6531_ $$aRisk assessment
000148607 6531_ $$aSurface Waters
000148607 6531_ $$aHuman Health
000148607 6531_ $$aDrugs
000148607 6531_ $$aFish
000148607 6531_ $$aEstrogens
000148607 6531_ $$aWales
000148607 700__ $$aPerazzolo, C.
000148607 700__ $$0243203$$aMorasch, B.$$g184239
000148607 700__ $$0240649$$aKohn, T.$$g173999
000148607 700__ $$aMagnet, A.
000148607 700__ $$aThonney, D.
000148607 700__ $$aChèvre, N.
000148607 773__ $$j29$$k8$$q1649–1657$$tEnvironmental Toxicology and Chemistry
000148607 8564_ $$s160455$$uhttps://infoscience.epfl.ch/record/148607/files/Perazzolo%20et%20al.pdf$$yn/a$$zn/a
000148607 909C0 $$0252156$$pLCE$$xU11718
000148607 909CO $$ooai:infoscience.tind.io:148607$$particle$$pENAC$$qGLOBAL_SET
000148607 917Z8 $$x104459
000148607 917Z8 $$x173999
000148607 917Z8 $$x173999
000148607 937__ $$aEPFL-ARTICLE-148607
000148607 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000148607 980__ $$aARTICLE