Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N-epsilon-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride
This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anchored polypeptide chains assume an a-helical conformation, which does not change between pH 4 and 9. Furthermore, nonspecific adsorption of fluorescent labeled bovine serum albumin and fibrinogen on glass slides modified with these brushes was greatly reduced compared to unmodified glass substrates.
Keywords: biomaterials and biological applications of polymers ; peptides ; ring-opening polymerization ; surfaces ; Self-Assembled Monolayers ; Glycol) ; Resistance ; Adhesion ; Protein ; Layers ; Gold
Record created on 2010-04-23, modified on 2016-08-08