Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N-epsilon-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride

This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anchored polypeptide chains assume an a-helical conformation, which does not change between pH 4 and 9. Furthermore, nonspecific adsorption of fluorescent labeled bovine serum albumin and fibrinogen on glass slides modified with these brushes was greatly reduced compared to unmodified glass substrates.


Published in:
Macromolecular Rapid Communications, 30, 9-10, 845-850
Year:
2009
ISSN:
1521-3927
Keywords:
Laboratories:




 Record created 2010-04-23, last modified 2018-01-28


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