000148423 001__ 148423
000148423 005__ 20190316234802.0
000148423 0247_ $$2doi$$a10.1117/12.854136
000148423 02470 $$2ISI$$a000285087700071
000148423 037__ $$aCONF
000148423 245__ $$aDetermination of local optical properties of the rat barrel cortex during neural activation: Monte-Carlo approach to light propagation
000148423 269__ $$a2010
000148423 260__ $$bSPIE$$c2010
000148423 336__ $$aConference Papers
000148423 490__ $$aProceedings of SPIE-The International Society for Optical Engineering
000148423 520__ $$aSpatially-spectrally-resolved reflectance measurements allow in vivo measuring the optical coefficients of absorption and scattering within the cortical tissue. This method, if applied to neural tissue during enhanced activity, could allow a straightforward monitoring of the blood oxygen saturation changes occurring in the brain cortex during hemodynamic responses. Furthermore, it may provide valuable information on possible absorption and scattering changes occurring during stimulation. The feasibility of such measurements was investigated by carrying a preliminary numerical study using a Monte-Carlo light propagation routine. Experimental parameters such as the geometry of the optical probe, baseline cortex optical coefficients retrieved from the literature and anatomical characteristics of the rat barrel cortex were used as an input for the simulations. The sensitivity of the probe to the local variations of optical coefficients was investigated with this numerical approach. Additionally, the influence of the barrel cortex dimensions and the probe positioning relatively to the activated region were studied for instrumental optimization purpose. It was found that typical variations of optical coefficients can be detected if the activated region of barrel cortex has a volume of typically 1 mm3 or larger. The decay of the probe sensitivity to changes was studied as a function of the depth of the activated region. The results showed that the best sensitivity is achieved by placing the light injection fiber of the optical probe aligned onto the center of the cylindrical barrel.
000148423 6531_ $$a[MVD]
000148423 700__ $$0242059$$g188408$$aMigacheva, Elena
000148423 700__ $$0242049$$g100786$$aChamot, Stéphane
000148423 700__ $$aSeydoux, Olivier
000148423 700__ $$aWeber, Bruno
000148423 700__ $$0240009$$g104931$$aDepeursinge, Christian
000148423 700__ $$aMarquet, Pierre
000148423 700__ $$aMagistretti, Pierre$$g134990$$0243698
000148423 7112_ $$dApril 13-15, 2010$$cBruxelles, Belgium$$aPhotonics Europe 2010
000148423 773__ $$j7715$$tBiophotonics: Photonic Solutions for Better Health Care II$$q771531
000148423 8564_ $$uhttp://spiedigitallibrary.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PSISDG007715000001771531000001&idtype=cvips&gifs=Yes&bproc=symp&scode=EPE10&ref=no$$zURL
000148423 909C0 $$xU10346$$0252008$$pLOA
000148423 909C0 $$0252265$$pLNDC$$xU11150
000148423 909CO $$qSV$$qGLOBAL_SET$$pconf$$pSTI$$ooai:infoscience.tind.io:148423
000148423 917Z8 $$x146896
000148423 917Z8 $$x146896
000148423 937__ $$aEPFL-CONF-148423
000148423 973__ $$rNON-REVIEWED$$sPUBLISHED$$aEPFL
000148423 980__ $$aCONF