An active implantable chemico-rheological sensor including control electronics, a Digital Signal Processor (DSP) and an RF transceiver has been demonstrated. The ultra-low power system architecture achieves an energy per viscosity measurement of only 16.6mJ of which 56% are dedicated to the micro-rheometer, 40% to the transceiver, and 4% to the DSP. Four coins batteries with a capacity of 150J each (Energizer 376) enabled a life time of 28’500 cycles at 37°C. The System in Package (SiP) fits in a 8.4mm in diameter cylinder and hence is implantable. As this generic system is fully programmable, it may further control any biosensor or bioactuator.