000148168 001__ 148168
000148168 005__ 20181203021849.0
000148168 022__ $$a1521-6543
000148168 0247_ $$2doi$$a10.1080/15216540050033078
000148168 037__ $$aARTICLE
000148168 245__ $$aErythropoiesis and molecular mechanisms for sexual determination in malaria parasites
000148168 269__ $$a2000
000148168 260__ $$bTaylor & Francis$$c2000
000148168 336__ $$aJournal Articles
000148168 520__ $$aMalaria parasites proliferate asexually within the vertebrate host but must undergo sexual reproduction for transmission to mosquitoes and hence infection of new hosts. The developmental pathways controlling gametocytogenesis are not known, but several protein kinases and other putative signal transduction elements possibly involved in this phenomenon have been found in Plasmodium. Recently, another developmental pathway, that of Plasmodium sex determination (male or female), has been shown to be triggered by erythropoiesis in the host. Rapid progress is being made in our understanding of the molecular basis of mammalian erythropoiesis, revealing kinase pathways that are essential to cellular responses triggered by the hormone erythropoietin. Although the molecular mechanisms whereby this hormone modulates the sex ratio of malaria parasites remain to be elucidated, it probably activates, within the parasite, transduction pathways similar to those found in other eukaryotes. Indeed, enzymes belonging to protein kinase families known to be involved in the response of mammalian cells to erythropoietin (such as the mitogen-activated protein kinases) have been identified in P. falciparum gametocytes. Some of these enzymes differ markedly from their mammalian homologs; therefore, identification of the transduction pathways of the parasite that are responsible for its developmental response to erythropoietin opens the way to the development of transmission-blocking drugs based on kinase inhibitors.
000148168 6531_ $$aSex Determination (Genetics)
000148168 700__ $$aPaul, R. E.
000148168 700__ $$0243705$$aDoerig, C.$$g191299
000148168 700__ $$aBrey, P. T.
000148168 773__ $$j49$$k4$$q245-8$$tIUBMB life
000148168 909C0 $$0252274$$pINSERM-EPFL$$xU12184
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000148168 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000148168 980__ $$aARTICLE