000148071 001__ 148071
000148071 005__ 20190527110247.0
000148071 0247_ $$2doi$$a10.1039/b912096c
000148071 022__ $$a1477-9226
000148071 02470 $$2ISI$$a000272359900013
000148071 037__ $$aARTICLE
000148071 245__ $$aExcellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles
000148071 260__ $$bRoyal Society of Chemistry$$c2009
000148071 269__ $$a2009
000148071 336__ $$aJournal Articles
000148071 520__ $$aThe reaction of the five- or six-membered C,N or C,S-palladacycles [(L)PdCl]2 with PTA (1,3,5-triaza-7-phosphaadamantane) led to the monomeric complexes [(L)Pd(PTA)Cl] 6a, 6b and 7 where LH= N,N-dimethyl-1-phenylmethanamine, benzyl(methyl)sulfane or 1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one resp. Dimeric complexes have also been synthesized: [Pd2L2(μ-dppe)Cl2], where LH = 1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one (1a), (R)- or (S)-3-isopropyl-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one (1b, 1c), [Pd2L2(μ-dppf)Cl2], where L= 1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one (4a) or (R)-3-isopropyl-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one (4b), resp., and dppe = 1,2-bis(diphenylphosphino)ethane, dppf = 1,1'-bis(diphenylphosphino)ferrocene. The complexes were characterized in soln., by 1H and 31P NMR spectroscopy, and single crystals of complexes 6b and 7 were studied in the solid state by x-ray crystallog. The palladacycles were evaluated for in vitro activity as cytotoxic agents on A2780/S cells and also as cathepsin B inhibitors, an enzyme implicated in a no. of cancer related events.
000148071 6531_ $$aLysosomal Cysteine Proteases
000148071 6531_ $$aBioorganometallic Chemistry
000148071 6531_ $$aBreast-Cancer
000148071 6531_ $$aComplexes
000148071 6531_ $$aProgression
000148071 6531_ $$aDrugs
000148071 6531_ $$aPharmaceuticals
000148071 6531_ $$aAu(I)
000148071 700__ $$aSpencer, John
000148071 700__ $$0242064$$g185115$$aCasini, Angela
000148071 700__ $$0242074$$g187546$$aZava, Olivier
000148071 700__ $$aRathnam, Rajendra P.
000148071 700__ $$aVelhanda, Santosh K.
000148071 700__ $$aPfeffer, Michel
000148071 700__ $$aCallear, Samantha K.
000148071 700__ $$aHursthouse, Michael B.
000148071 700__ $$aDyson, Paul J.$$g149418$$0240015
000148071 773__ $$j48$$tDalton Transactions$$q10731-10735
000148071 909C0 $$xU9$$0252010$$pLCOM
000148071 909CO $$pSB$$particle$$ooai:infoscience.tind.io:148071
000148071 937__ $$aEPFL-ARTICLE-148071
000148071 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000148071 980__ $$aARTICLE