000147770 001__ 147770
000147770 005__ 20190522142432.0
000147770 0247_ $$2doi$$a10.1016/j.bulm.2005.02.001
000147770 022__ $$a00928240
000147770 02470 $$2ISI$$a000232516300006
000147770 037__ $$aARTICLE
000147770 245__ $$aEmergent properties of electrically coupled smooth muscle cells
000147770 260__ $$c2005$$bSpringer-Verlag
000147770 269__ $$a2005
000147770 336__ $$aJournal Articles
000147770 500__ $$aNational Licences
000147770 520__ $$aAsynchronous and synchronous calcium oscillations occur in a variety of cells. A well-established pathway for intercellular communication is provided by gap junctions which connect adjacent cells and can mediate electrical and chemical coupling. Several experimental studies report that cells presenting only a transient increase when freshly dispersed may oscillate when they are coupled. Such observations suggest that the role of gap junctions is not only to coordinate calcium oscillations of adjacent cells. Gap junctions may also be important to generate oscillations. Here we illustrate the emergent properties of electrically coupled smooth muscle cells using a model that we recently proposed. A bifurcation analysis in the case of two cells reveals that synchronous and asynchronous calcium oscillations can be induced by electrical coupling. In a larger population of smooth muscle cells, electrical coupling may result in the creation of groups of cells presenting synchronous calcium oscillations. The elements of one group may be distant from each other. Moreover, our results highlight a general mechanism by which gap junctional electrical coupling can give rise to out of phase calcium oscillations in smooth muscle cells that are non-oscillating when uncoupled. All these observations remain true in the case of non-identical cells, except that the solution corresponding to synchronous calcium oscillations disappears and that the formation of groups is sensitive to the degree of heterogeneity. © 2005 Society for Mathematical Biology. Published by Elsevier Ltd. All rights reserved.
000147770 700__ $$aKoenigsberger, M.
000147770 700__ $$aSauser, R.
000147770 700__ $$g105816$$aMeister, J.-J.$$0240339
000147770 773__ $$j67$$tBulletin of Mathematical Biology$$k6$$q1253-1272
000147770 8564_ $$uhttps://infoscience.epfl.ch/record/147770/files/11538_2006_Article_2001.pdf$$zPUBLISHER'S VERSION$$s2649269
000147770 909C0 $$xU10146$$0252255$$pLCB
000147770 909CO $$pSB$$particle$$ooai:infoscience.tind.io:147770
000147770 937__ $$aEPFL-ARTICLE-147770
000147770 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000147770 980__ $$aARTICLE