Mechanical properties of individual microtubules measured using atomic force microscopy

Atomic force microscopy has been used to investigate the mechanical properties of microtubules. Method of Salvetat et al. [1], originally developed for measuring the Young's modulus of carbon nanotubes, has been extended to a biological system of similar geometry. Preliminary measurements of Young's modulus of microtubules in this configuration give a value of 74 MPa. Compression measurements on the same system give a value of 22 MPa, which is of the same order of magnitude, while values previously reported in the literature have a dispersion of 3 orders in magnitude, from 1MPa to 1GPa. Further improvements of our method will enable comparison between the properties of different types of microtubules, for example, between those from healthy and diseased tissue.


Publié dans:
Electronic Properties Of Novel Materials-Molecular Nanostructures, 544, 482-486
Présenté à:
14th International Winter School on Electronic Properties on Novel Materials, KIRCHBERG, AUSTRIA, Mar 04-11, 2000
Année
2000
Publisher:
Amer. Inst. Physics, 2 Huntington Quadrangle, Ste 1No1 D, Melville, Ny 11747-4501 Usa
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Note: Le statut de ce fichier est: Seulement EPFL


 Notice créée le 2010-03-19, modifiée le 2019-12-05

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