Nanomechanics of Microtubules

We have determined the mechanical anisotropy of a single microtubule by simultaneously measuring the Young's and the shear moduli in vitro. This was achieved by elastically deforming the microtubule deposited on a substrate tailored by electron-beam lithography with a tip of an atomic force microscope. The shear modulus is 2 orders of magnitude lower than the Young's, giving rise to a length-dependent flexural rigidity of microtubules. The temperature dependence of the microtubule's bending stiffness in the (5-40) degreesC range shows a strong variation upon cooling coming from the increasing interaction between the protofilaments.


Published in:
Physical Review Letters, 89, 24
Year:
2002
Publisher:
American Physical Society
ISSN:
1079-7114
Keywords:
Laboratories:




 Record created 2010-03-19, last modified 2018-01-28

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