Infoscience

Conference paper

Waveguide fluorosensor for the detection of ligand-receptor interactions - The 5-HT3 serotonin receptor

A highly-sensitive surface fluorescence technique was combined with a powerful method for the oriented reversible immobilization of membrane proteins on oxide surfaces. Affinity and kinetic parameters of the interaction of the receptor and a fluorescent ligand were evaluated. The approach is particularly suited for the study of rapid ligand-receptor interactions where optimized cell volume, flow and injection conditions are required.

    Reference

    • EPFL-CONF-147345

    Record created on 2010-03-17, modified on 2016-08-08

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