Nickel-Titanium (NiTi) shape memory alloys are often used in medical component devices, for instance as guide wires for neurological surgery applications. The manufacture of such devices becomes more and more challenging, especially considering the need to join them with other metals. Laser welding is a promising technique to realize and to guaranty the mechanical stability of dissimilar metal welds, although inherent differences in chemical compositions, absorption, physical and thermo-mechanical properties can lead to severe problems, in particular fracture of the weld due to the possible formation of brittle intermediate phases. Laser welds of NiTi - stainless steel (SS) pieces have been made with a Nd:YAG laser and the weld microstructure have been studied by Scanning Electron Microscopy (SEM). The phases and defects in these welds have been compared with those observed in autogenous NiTi welds and SS welds. They have been put into relation with the Fe-Ni-Ti ternary phase diagram. In addition, Differential Thermal Analyses (DTA) of NiTi-SS alloys and NiTi-SS diffusion couple experiments have been performed in order to gain a better understanding of the phases and reactions occurring during laser welding. This diffusive couple experiments have been analyzed by Energy Dispersive X-ray Spectroscopy (EDX) It appeared that although experiments were performed under controlled atmosphere, oxide layers have restrained the chemical diffusion of concerned elements. Further diffusion couple experiments will be realized with stainless steel welded caps to avoid oxygen contamination during heating.