Understanding parkinsonian handwriting through a computational model of basal ganglia

Handwriting in Parkinson's disease (PD) is typically characterized by micrographia, jagged line contour, and unusual fluctuations in pen tip velocity. Although PD handwriting features have been used for diagnostics, they are not based on a signaling model of basal ganglia (BG). In this letter, we present a computational model of handwriting generation that highlights the role of BG. When PD conditions like reduced dopamine and altered dynamics of the subthalamic nucleus and globus pallidus externa subsystems are simulated, the handwriting produced by the model manifested characteristic PD handwriting distortions like micrographia and velocity fluctuations. Our approach to PD modeling is in tune with the perspective that PD is a dynamic disease.


Published in:
Neural Computation, 20, 10, 2491-2525
Year:
2008
Publisher:
Massachusetts Institute of Technology Press
ISSN:
0899-7667
Laboratories:




 Record created 2010-02-14, last modified 2018-03-17


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