We study theoretically superfluidity in a driven-dissipative Bose gas out of thermal equilibrium, and discuss the relation with conventional superfluids. We show how the superfluid behavior is characterized by a dramatic increase in the lifetime of a quantized vortex and point out the influence of the spatial geometry of the condensate. We apply our study to a condensate of polaritons in a semiconductor microcavity, whose properties can be directly inferred from optical spectroscopy. We propose three different experimental schemes to measure the vorticity of the polariton condensate.