The Nickel/Copper-Catalyzed Direct Alkylation of Heterocyclic C-H Bonds

A general and straightforward protocol for the cross-coupling of non-activated alkyl halides with heterocyclic CH bonds has been developed. The transformation is chemo- and regioselective and many functional groups on both coupling partners are tolerated. The method employs cheap nickel/copper catalysts, and expands significantly the scope of CH functionalization.


Published in:
Angewandte Chemie International Edition, 49, 17, 3061-3064
Year:
2010
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 Record created 2010-01-22, last modified 2018-03-17

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