Biomechanics in bone tissue engineering
Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach, so are aspects of interface micromotion, bone ingrowths inside the scaffold and finally the mechanical integrity of the scaffold during its degradation. A proposed view is presented herein on how biomechanical aspects can be synthesized and where future developments are needed. In particular, a distinction is made between the mechanical and the mechanotransductional aspects in bone tissue engineering: the former could be related to osteoconduction, while the later may be correlated to the osteoinductive properties of the scaffold. This distinction allows biomechanicians to follow a strategy in the development of a scaffold having not only mechanical targets, but also incorporating some mechanotransduction principles.
Keywords: bone scaffold ; load-bearing application ; biomechanics ; mechanotransduction ; tissue engineering ; Mesenchymal Stem-Cells ; Finite-Element ; Osteogenic Differentiation ; Biophysical Principles ; Mechanical-Properties ; Trabecular Bone ; Fluid-Flow ; In-Vitro ; Scaffolds ; Regeneration
Record created on 2010-01-19, modified on 2016-08-08