Biomechanics in bone tissue engineering

Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach, so are aspects of interface micromotion, bone ingrowths inside the scaffold and finally the mechanical integrity of the scaffold during its degradation. A proposed view is presented herein on how biomechanical aspects can be synthesized and where future developments are needed. In particular, a distinction is made between the mechanical and the mechanotransductional aspects in bone tissue engineering: the former could be related to osteoconduction, while the later may be correlated to the osteoinductive properties of the scaffold. This distinction allows biomechanicians to follow a strategy in the development of a scaffold having not only mechanical targets, but also incorporating some mechanotransduction principles.


Published in:
Computer Methods In Biomechanics And Biomedical Engineering, 13, 837-846
Year:
2010
Publisher:
Taylor & Francis
ISSN:
1025-5842
Keywords:
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 Record created 2010-01-19, last modified 2018-03-17

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