000143418 001__ 143418
000143418 005__ 20180913055605.0
000143418 0247_ $$2doi$$a10.1016/j.jpsychires.2010.01.005
000143418 02470 $$2PMID$$a20172535
000143418 02470 $$2ISI$$a000282398800002
000143418 037__ $$aARTICLE
000143418 245__ $$aRegulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment
000143418 269__ $$a2010
000143418 260__ $$bElsevier$$c2010
000143418 336__ $$aJournal Articles
000143418 520__ $$aChronic unpredictable stress (CUS) is a widely used animal model of depression. The present study was undertaken to investigate behavioral, physiological and molecular effects of CUS and/or chronic antidepressant treatment (venlafaxine or imipramine) in the same set of animals. Anhedonia, a core symptom of depression, was assessed by measuring consumption of a palatable solution. Exposure to CUS reduced intake of a palatable solution and this effect was prevented by chronic antidepressant treatment. Moreover, chronic antidepressant treatment decreased depressive-like behavior in a modified forced swim test in stressed rats. Present evidence suggests a role for brain-derived neurotrophic factor (BDNF) in depression. BDNF mRNA levels in the ventral and dorsal hippocampus were assessed by in situ hybridization. Exposure to CUS was not correlated with a decrease but rather with an increase in BDNF mRNA expression in both the dentate gyrus of the dorsal hippocampus and the CA3 region of the ventral hippocampus indicating that there is no simple link between depression-like behaviors per se and brain BDNF levels in rats. However, a significant increase in BDNF mRNA levels in the dentate gyrus of the dorsal hippocampus correlated with chronic antidepressant treatment emphasizing a role for BDNF in the mechanisms underlying antidepressant activity.
000143418 6531_ $$aChronic unpredictable stress
000143418 6531_ $$aDepression
000143418 6531_ $$aAntidepressants
000143418 6531_ $$aBrain-derived neurotrophic factor
000143418 6531_ $$aHippocampus
000143418 6531_ $$aAnhedonia
000143418 6531_ $$aChronic Mild Stress
000143418 6531_ $$aFactor Protein-Levels
000143418 6531_ $$aTrkb Messenger-Rna
000143418 6531_ $$aMajor Depression
000143418 6531_ $$aGene-Expression
000143418 6531_ $$aVentral Hippocampus
000143418 6531_ $$aChronic Imipramine
000143418 6531_ $$aRestraint Stress
000143418 6531_ $$aFear Expression
000143418 6531_ $$aMood Disorders
000143418 700__ $$aLarsen, Marianne H.
000143418 700__ $$aMikkelsen, Jens D.
000143418 700__ $$aHay-Schmidt, Anders
000143418 700__ $$0243016$$aSandi, Carmen$$g160090
000143418 773__ $$j44$$q808-16$$tJ Psychiatr Res
000143418 8564_ $$s436728$$uhttps://infoscience.epfl.ch/record/143418/files/Larsen-Regulation%20of%20brain-derived%20neurotrophic.pdf$$yn/a$$zn/a
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000143418 937__ $$aEPFL-ARTICLE-143418
000143418 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000143418 980__ $$aARTICLE