000143192 001__ 143192
000143192 005__ 20181228151102.0
000143192 022__ $$a0378-5866
000143192 02470 $$2PMID$$a8940604
000143192 0247_ $$2doi$$a10.1159/000111426
000143192 037__ $$aARTICLE
000143192 245__ $$aExcitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPase
000143192 269__ $$a1996
000143192 260__ $$c1996
000143192 336__ $$aJournal Articles
000143192 520__ $$aAstrocytes appear to be ideally localized to couple neuronal activity to energy metabolism. First, specialized processes, the astrocytic end-feet surround blood vessels, the source of glucose for the brain. Second, other processes ensheath synapses and express receptors and transporters for various neurotransmitters, endowing astrocytes with the capacity to 'sense' synaptic activity. We have previously described the stimulation by L-glutamate of glucose utilization by astrocytes, monitored by 2-deoxyglucose uptake and phosphorylation. Here we have further characterized the pharmacological characteristics and molecular mechanisms of this action, which involve a massive influx of Na+ as a result of the cotransport of the amino acid with Na+, by Na(+)-dependent transporters and a subsequent activation of the Na+/K+ ATPase. To fuel the ATPase, glucose is processed glycolytically thus leading to increased lactate production. Since excitatory amino acids are released during activation by cortical afferents, these data reveal a simple mechanism for coupling neuronal activity to glucose utilization and provide further evidence for the concept of a transient stimulation of aerobic glycolysis during activation occurring preferentially in astrocytes.
000143192 700__ $$aPellerin, L
000143192 700__ $$0243698$$aMagistretti, P J$$g134990
000143192 773__ $$j18$$k5-6$$q336-42$$tDevelopmental neuroscience
000143192 909C0 $$0252265$$pLNDC$$xU11150
000143192 909CO $$ooai:infoscience.tind.io:143192$$particle$$qSV
000143192 937__ $$aLNDC-ARTICLE-1996-006
000143192 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000143192 980__ $$aARTICLE