The functions of mucosal T cells in containing the indigenous commensal flora of the intestine

There is an immense load of non-pathogenic commensal bacteria in the distal small intestine and the colon of mammals. The physical barrier that prevents penetration (translocation) of these organisms into the body is a simple epithelium comprised of the single enterocyte/colonocyte cell layer with its overlying mucus. In this review, we discuss the roles of intestinal T cells in initiating and regulating innate and adaptive mucosal immune responses of the mucosal immune system that avoid or limit penetration of the commensal intestinal bacteria.


Published in:
Cellular and Molecular Life Sciences, 59, 12, 2088-2096
Year:
2002
Keywords:
Note:
639JM Times Cited:9 Cited References Count:86
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 Record created 2010-01-07, last modified 2018-03-17

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