The functions of mucosal T cells in containing the indigenous commensal flora of the intestine
There is an immense load of non-pathogenic commensal bacteria in the distal small intestine and the colon of mammals. The physical barrier that prevents penetration (translocation) of these organisms into the body is a simple epithelium comprised of the single enterocyte/colonocyte cell layer with its overlying mucus. In this review, we discuss the roles of intestinal T cells in initiating and regulating innate and adaptive mucosal immune responses of the mucosal immune system that avoid or limit penetration of the commensal intestinal bacteria.
Keywords: intraepithelial lymphocyte ; lamina propria lymphocyte ; iga ; commensal bacteria ; macrophage ; intestinal mucosa ; germ-free mice ; intraepithelial lymphocytes ; bacterial translocation ; microbial colonization ; interferon-gamma ; immune-response ; lamina propria ; deficient mice ; iga responses ; cholera-toxin
639JM Times Cited:9 Cited References Count:86
Record created on 2010-01-07, modified on 2016-08-08