Natural IgE production in the absence of MHC Class II cognate help
IgE induction by parasites and allergens is antigen driven and cognate T cell help dependent. We demonstrate that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help. This does not require secondary lymphoid structures or germinal center formation, although some bystander T cell-derived IL-4 is necessary. The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals.
Keywords: Animals ; Antibodies, Helminth/biosynthesis ; B-Lymphocytes/physiology ; Histocompatibility Antigens Class II/*physiology ; Immunoglobulin E/*biosynthesis ; Interleukin-4/physiology ; Mast Cells/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred ICR ; T-Lymphocytes/physiology ; T-Lymphocytes, Regulatory/physiology
McCoy, Kathy D Harris, Nicola L Diener, Philipp Hatak, Sarah Odermatt, Bernhard Hangartner, Lars Senn, Beatrice M Marsland, Benjamin J Geuking, Markus B Hengartner, Hans Macpherson, Andrew J S Zinkernagel, Rolf M Research Support, Non-U.S. Gov't United States Immunity Immunity. 2006 Mar;24(3):329-39.
Record created on 2010-01-06, modified on 2016-08-08