Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation

Persistence is a hallmark of infection by viruses such as HIV, hepatitis B virus, hepatitis C virus and LCMV. In the case of LCMV, persistence may often be associated with exhaustion of CD8(+) T cells. We demonstrate here that persistent antigen suppressed IL-7Ralpha expression and this correlated with T cell exhaustion and reduced expression of the anti-apoptotic molecule B cell leukemia/lymphoma 2 (Bcl-2). In contrast, exposure to short-lived antigen only temporarily suppressed IL-7Ralpha expression, failed to induce T cell exhaustion, and primed T cells. Persistent antigen also suppressed IL-7Ralpha expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate.


Published in:
Eur J Immunol, 35, 3, 738-45
Year:
2005
Keywords:
Note:
Lang, Karl S Recher, Mike Navarini, Alexander A Harris, Nicola L Lohning, Max Junt, Tobias Probst, Hans Christian Hengartner, Hans Zinkernagel, Rolf M Research Support, Non-U.S. Gov't Germany European journal of immunology Eur J Immunol. 2005 Mar;35(3):738-45.
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