Deliberate removal of T cell help improves virus-neutralizing antibody production

The B cell response to lymphocytic choriomeningitis virus is characterized by a CD4(+) T cell-dependent polyclonal hypergammaglobulinemia and delayed formation of virus-specific neutralizing antibodies. Here we provide evidence that, paradoxically, because of polyclonal B cell activation, virus-specific T cell help impairs the induction of neutralizing antibody responses. Experimental reduction in CD4(+) T cell help in vivo resulted in potent neutralizing antibody responses without impairment of CD8(+) T cell activity. These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found.


Published in:
Nat Immunol, 5, 9, 934-42
Year:
2004
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Recher, Mike Lang, Karl S Hunziker, Lukas Freigang, Stefan Eschli, Bruno Harris, Nicola L Navarini, Alexander Senn, Beatrice M Fink, Katja Lotscher, Marius Hangartner, Lars Zellweger, Raphael Hersberger, Martin Theocharides, Alexandre Hengartner, Hans Zinkernagel, Rolf M Research Support, Non-U.S. Gov't United States Nature immunology Nat Immunol. 2004 Sep;5(9):934-42. Epub 2004 Aug 8.
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