In this paper we study the relay-interference wireless network, in which relay (helper) nodes are to facilitate competing information ﬂows over a wireless network. We examine this in the context of a deterministic wireless interaction model, which eliminates the channel noise and focuses on the signal interactions. Using this model, we show that almost all the known schemes such as interference suppression, interference alignment and interference separation are necessary for relay-interference networks. In addition, we discover a new interference management technique, which we call interference neutralization, which allows for over-the-air interference removal, without the transmitters having complete access the interfering signals. We show that interference separation, suppression, and neutralization arise in a fundamental manner, since we show complete characterizations for special conﬁgurations of the relay-interference network.