Structural properties of pore-forming oligomers of alpha-synuclein

Soluble oligomers are potent toxins in many neurodegenerative diseases, but little is known about the structure of soluble oligomers and their structure-toxicity relationship. Here we prepared on-pathway oligomers of the 140-residue protein alpha-synuclein, a key player in Parkinson's disease, at concentrations an order of magnitude higher than previously possible. The oligomers form ion channels with well-defined conductance states in a variety of membranes, and their beta-structure differs from that of amyloid fibrils of alpha-synuclein.


Published in:
Journal of the American Chemical Society, 131, 47, 17482-17489
Year:
2009
Publisher:
American Chemical Society
ISSN:
0002-7863
Keywords:
Laboratories:




 Record created 2009-10-29, last modified 2018-03-17

n/a:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)