000142119 001__ 142119
000142119 005__ 20190416055735.0
000142119 022__ $$a1064-3745
000142119 02470 $$2PMID$$a15980593
000142119 0247_ $$2doi$$a10.1385/1-59259-874-9:019
000142119 037__ $$aARTICLE
000142119 245__ $$aIn vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein
000142119 269__ $$a2005
000142119 260__ $$bHumana Press$$c2005
000142119 336__ $$aJournal Articles
000142119 520__ $$aElucidating the structural properties of early intermediates (protofibrils) on the fibril formation pathway of Abeta and alpha-synuclein, the structural relationship among the different intermediates and their relationship to the structure of the amyloid fibrils is critical for understanding the roles of amyloid fibril formation in the pathogenesis of Alzheimer's and Parkinson's diseases. In this chapter we discuss several methods, developed by different laboratories, that enable the preparation and stabilization of amyloid-beta and alpha-synuclein protofibrillar species of defined morphologies for biochemical, biophysical and toxicity studies.
000142119 700__ $$0240880$$g167337$$aLashuel, Hilal A.
000142119 700__ $$aGrillo-Bosch, Dolors
000142119 773__ $$j299$$tMethods in molecular biology (Clifton, N.J.)$$q19-33
000142119 8564_ $$uhttps://infoscience.epfl.ch/record/142119/files/26.pdf$$zn/a$$s4133005$$yn/a
000142119 909C0 $$xU11104$$0252159$$pLMNN
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000142119 909CO $$qGLOBAL_SET$$pSV$$pSTI$$particle$$ooai:infoscience.tind.io:142119
000142119 917Z8 $$x183492
000142119 917Z8 $$x171169
000142119 937__ $$aLMNN-ARTICLE-2005-005
000142119 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000142119 980__ $$aARTICLE