000141990 001__ 141990
000141990 005__ 20190316234633.0
000141990 02470 $$2ISI$$a000272211300108
000141990 037__ $$aCONF
000141990 245__ $$aDynamical Spot Queries to Improve Specificity in P450s based Multi-Drugs Monitoring
000141990 269__ $$a2009
000141990 260__ $$c2009
000141990 336__ $$aConference Papers
000141990 520__ $$aPersonalized therapy requires accurate and frequent monitoring of drugs metabolic response in living organisms during drug treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecules cocktails, direct monitoring of the patient’s drug metabolism is essential as the metabolic pathways efficacy is highly variable on a patient-bypatient basis. Moreover, anti-cancer pharmacological treatments are often based on cocktails of different drugs. Currently, there are no fully mature biochip systems to monitor multi-panel drugs amount in blood or in serum. The aim of this paper is to investigate the complexity of multiple drugs detection for point-of-care systems to be used in personalized therapy. Probes molecules for the biochip are the P450 enzymes as they have key role in drugs metabolism. Multiple drugs detection is carried out both by simulations and electrochemical experiments. Drugs specificity enhancement is investigated considering components decomposition of peak as registered in cyclic voltammetry acquisitions. This investigation has the aim to identify crucial aspect in VLSI design of fully-electronics biochip development in this field.
000141990 6531_ $$aDirect Electron-Transfer
000141990 6531_ $$aHuman Liver-Microsomes
000141990 6531_ $$aCytochrome P450Scc
000141990 6531_ $$aCyp2D6
000141990 6531_ $$aMetabolism
000141990 6531_ $$aElectrochemistry
000141990 6531_ $$aNanoparticles
000141990 6531_ $$aBiochemistry
000141990 6531_ $$aGenetics
000141990 6531_ $$aTherapy
000141990 700__ $$0242413$$g182237$$aCarrara, Sandro
000141990 700__ $$0242421$$g176841$$aCavallini, Andrea
000141990 700__ $$g165204$$aGarg, Abhishek$$0240151
000141990 700__ $$g167918$$aDe Micheli, Giovanni$$0240269
000141990 7112_ $$dApril 9-11, 2009$$cTempe, Arizona, USA$$aIEEE/ICME International Conference on Complex Medical Engineering
000141990 773__ $$tProceedings of the IEEE/ICME International Conference on Complex Medical Engineering$$q1-6
000141990 8564_ $$uhttps://infoscience.epfl.ch/record/141990/files/Dynamical_Spot_pdf.pdf$$zn/a$$s368233$$yn/a
000141990 909C0 $$xU11140$$0252283$$pLSI1
000141990 909CO $$pIC$$ooai:infoscience.tind.io:141990$$qGLOBAL_SET$$pconf$$pSTI
000141990 917Z8 $$x176271
000141990 917Z8 $$x112915
000141990 917Z8 $$x112915
000141990 917Z8 $$x112915
000141990 937__ $$aEPFL-CONF-141990
000141990 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000141990 980__ $$aCONF