Novel chemico-mechanical approach towards long-term implantable glucose sensing

The proof of concept of a continuously sensing affinity device based on the glucose-dependent viscosity of a sensitive solution containing dextran and Concanavalin A has been successfully demonstrated. The biosensor incorporates a piezoelectric diaphragm and a flow-resisting microchannel for viscosity detection, and a free-standing Anodic Alumina Oxide (AAO) porous nano-membrane as glucose selective interface. Extensive in vitro glucose measurements between two physiologically relevant glucose concentrations, 2 mM and 9 mM (respectively hypo- and hyperglycemia), were successfully performed during 4 days. To the best of our knowledge, such reversibility and stability of glucose measurement over time had not been reported yet.


Published in:
Proceedings of the Eurosensors XXIII conference, 1, 1, 313-316
Presented at:
Eurosensors XXIII, Lausanne, Switzerland, September 7-9, 2009
Year:
2009
Publisher:
Amsterdam, Elsevier
Keywords:
Laboratories:




 Record created 2009-10-02, last modified 2018-01-28

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