In centrifugal pumps, the interaction between the rotating impeller and the stationary diffuser generates specific pressure fluctuation patterns. When the pump is operated at off design conditions, these pressure fluctuations increase. The resulting rise of mechanical vibration levels may negatively affect the operational performance and the life span of mechanical components. This paper presents detailed pressure fluctuation measurements performed in a high speed centrifugal pump stage at full scale at various operating conditions. The impeller and stationary part (diffuser, exit chamber) of the pump stage have been equipped with piezo-resistive miniature pressure sensors. The measured data in the impeller have been acquired using a newly developed onboard data acquisition system, designed for rotational speeds up to 6000 rpm. The measurements have been performed synchronously in the rotating and stationary domains. The analysis of pressure fluctuations at the impeller blade trailing edge, which had significantly larger amplitudes as the pressure fluctuations in the stationary domain, allowed the detection and exploration of stalled channels in the vaned diffuser. This stall may be stationary or rotating with different rotational speeds and number of stalled channels, depending on the relative flow rate and the rotational speed of the pump. The stall yields pressure fluctuations at frequencies which are multiples of the rotational speed of the impeller and generates additional sources of mechanical excitation.