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research article
Ni-Catalyzed Sonogashira Coupling of Non-activated Alkyl Halides: Orthogonal Functionalization of Alkyl Iodides, Bromides, and Chlorides
Ni-catalyzed Sonogashira coupling of nonactivated, β-H- containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl halide, in both coupling partners. The coupling can be selective for a specific C−X bond (X = I, Br, Cl) and allows for orthogonal functionalization of alkyl halides with multiple reactive sites.
Use this identifier to reference this record
Type
research article
Web of Science ID
WOS:000269379600029
Authors
Publication date
2009
Published in
Volume
131
Issue
34
Start page
12078
End page
12079
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 6, 2009