The "complex-in-a-complex" cations [(acac)2M.cntnd.Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells

The cytotoxicities of the large cationic arene-ruthenium prismatic cage [Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+ (tpt = 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine, dhbq = 2,5-dihydroxy-1,4-benzoquinolato; 16+), and its "complex-in-a-complex" derivs. [(acac)2M-1]6+ (M = Pd, Pt; acac = acetylacetonate), are evaluated in comparison with free [M(acac)2]. The differences in cytotoxicity suggest that, like a "Trojan Horse", leaching of the guest from the cage once inside a cell accelerates and increases the cytotoxic effect.


Published in:
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, 47, 20, 3773-3776
Year:
2008
Other identifiers:
Laboratories:




 Record created 2009-07-15, last modified 2018-03-17


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