Rational Design of an Organometallic Glutathione Transferase Inhibitor
Ang, Wee Han; Parker, Lorien J.; De Luca, Anastasia; Juillerat-Jeanneret, Lucienne; Morton, Craig J.; Lo Bello, Mario; Parker, Michael W.; Dyson, Paul J.
2009

Abstract

Double trouble: A hybrid org.-inorg. (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the org. moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophys. and biochem. methods.

Details

Title Rational Design of an Organometallic Glutathione Transferase Inhibitor
Author(s) Ang, Wee Han ; Parker, Lorien J. ; De Luca, Anastasia ; Juillerat-Jeanneret, Lucienne ; Morton, Craig J. ; Lo Bello, Mario ; Parker, Michael W. ; Dyson, Paul J.
Published in ANGEWANDTE CHEMIE, INTERNATIONAL EDITION
Volume 48
Issue 21
Pages 3854-3857
Date 2009
Keywords
DOI https://doi.org/10.1002/anie.200900185
Other identifier(s) View record in Web of Science
Laboratories LCOM
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2009-06-11