Abstract

Tissue engineering scaffolds are porous structures that allow bone cells to reside and produce bone. This process involves migration and differentiation of mesenchymal stromal cells and production of cartilage and bone by chondrocytes and osteoblasts, which is basically a bone healing process. Based on a mechanistic model of fracture healing, a 2D model of bone formation inside scaffold will be developed. Extensive experimental data from an in vivo study is available which will be used to verify the results of this mathematical model. This project demands working with MATLAB and COMSOL. A good mathematical background is highly recommended.

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