CMOS DNA sensor array with integratedA/D conversion based on label-free capacitance measurement

This paper presents a fully electronic label-free DNA chip in 0.5-mu m CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated.


Published in:
Ieee Journal of Solid-State Circuits, 41, 12, 2956-2964
Year:
2006
ISSN:
0018-9200
Laboratories:




 Record created 2009-05-12, last modified 2018-09-13


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