Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation/differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.


Published in:
Journal of molecular endocrinology, 27, 1, 1-9
Year:
2001
ISSN:
0952-5041
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 Record created 2009-04-02, last modified 2018-03-17


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