000135424 001__ 135424
000135424 005__ 20180913055145.0
000135424 022__ $$a0950-1991
000135424 02470 $$2PMID$$a1280557
000135424 037__ $$aARTICLE
000135424 245__ $$aPerturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models
000135424 269__ $$a1992
000135424 260__ $$c1992
000135424 336__ $$aJournal Articles
000135424 520__ $$aLiver lipoprotein lipase (LPL) and alpha-fetoprotein (AFP) gene expression show similar developmental patterns. Both mRNAs are abundantly expressed in neonatal rat liver and gradually disappear upon ageing. Treatment with fibric acid derivatives, such as fenofibrate, not only delays the developmental extinction of the LPL gene, but also increases LPL mRNA levels in neonatal rat liver. Similarly, the developmental extinction of the AFP gene in the liver is clearly delayed after fenofibrate. In adult rat liver, fibric acid derivatives transcriptionally reinduce a mRNA with similar size as LPL, but no effect on AFP mRNA was detected. Sequence comparison of clones isolated from a fenofibrate-induced cDNA library demonstrates that the fenofibrate-(re)induced mRNA in adult rat liver is encoding for LPL. The induction of LPL after fenofibrate is tissue-specific, since heart and adipose tissue LPL mRNA levels remain unchanged. In conclusion, fibric acid derivatives modulate developmental expression patterns in rat liver, and may selectively reinduce the expression of extinct genes in adult rat liver.
000135424 6531_ $$aGenes
000135424 6531_ $$aDevelopmental
000135424 700__ $$aStaels, B
000135424 700__ $$0240040$$aAuwerx, J$$g185233
000135424 773__ $$j115$$k4$$q1035-43$$tDevelopment (Cambridge, England)
000135424 909C0 $$0252023$$pNCEM$$xU11905
000135424 909CO $$ooai:infoscience.tind.io:135424$$pSV$$particle
000135424 937__ $$aNCEM-ARTICLE-1992-004
000135424 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000135424 980__ $$aARTICLE