000133678 001__ 133678
000133678 005__ 20181203021436.0
000133678 0247_ $$2doi$$a10.1021/op025605p
000133678 02470 $$2DAR$$a3620
000133678 02470 $$a000183051400010$$2ISI
000133678 037__ $$aARTICLE
000133678 245__ $$aScale-Up of Polymerization Process: A Practical Example
000133678 269__ $$a2003
000133678 260__ $$c2003
000133678 336__ $$aJournal Articles
000133678 500__ $$aCAN 138:354413
000133678 500__ $$a35-10
000133678 500__ $$aChemistry of Synthetic High Polymers
000133678 500__ $$aSwiss Federal Institute of Technology (EPFL), Institute of Chemical and Biological Process Science (SB-ISP-UPRE),Lausanne,Switz.
000133678 500__ $$aJournal
000133678 500__ $$a1083-6160
000133678 500__ $$awritten in English.
000133678 500__ $$a9003-53-6P (Polystyrene); 9011-14-7P (PMMA) Role: SPN (Synthetic preparation), PREP (Preparation) (practical examples of scale-up polymn. process for PMMA and polystyrene prodn. in comparison with model calcns.)
000133678 520__ $$aThe scale-up/-down of polymn. reactors has to deal with large viscosity changes during the process, addressing mass- and heat-transfer issues. A practical example on scale-up of styrene and Me methacrylate free radical bulk and soln. polymn. is presented. The main crit. parameters are mixing at mol. level (micromixing) and heat removal capacity. The operating parameters being kept const. are: reaction conditions (temp., pressure, chem.) and thus the reaction time. A pilot plant issued from scale-down of possible industrial sizes was developed to represent, at best, larger scales. The main parameter being scaled-up is the heat removal capacity, which has to be maintained const. among the different sizes. New concepts are adapted to dissipate the mixing energy where it is the most suitable, and the final step is the scale-up/-down strategy. Another issue addressed in this contribution is the need for in-line analytics that could operate at different plant scales and thus give important information for process control. Scale-up/-down strategy must include the whole process, not only the reaction stage but also what happens before, after, and simultaneously, i.e., upstream, downstream, and peripheral operations. Finally the measurable success of a scale-up/-down anal. could only be proved at industrial scale, where a good agreement between pilot- and larger scale should be obsd. The concepts in terms of transfer phenomena, analytics, sepn., product properties, feasibility, and economics should also be included in this anal.
000133678 6531_ $$aMixing (energy; practical examples of scale-up polymn. process for PMMA and polystyrene prodn. in comparison with model calcns. taking into consideration micromixing energy); Heat transfer; Polymerization; Polymerization apparatus (practical examples of scale-up polymn. process for PMMA and polystyrene prodn. in comparison with model calcns.); Chemical engineering design (scale-up; practical examples of scale-up polymn. process for PMMA and polystyrene prodn. in comparison with model calcns.)
000133678 6531_ $$ascale up polymn process PMMA polystyrene prodn; heat removal mixing energy assessment scale up polymn process
000133678 700__ $$g105841$$aMeyer, Thierry$$0241136
000133678 773__ $$j7$$tOrganic Process Research & Development$$k3$$q297-302
000133678 909C0 $$xU10177$$0252137$$pGSCP
000133678 909CO $$pSB$$particle$$ooai:infoscience.tind.io:133678
000133678 937__ $$aGSCP-ARTICLE-2003-002
000133678 970__ $$a0000000022/GSCP
000133678 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000133678 980__ $$aARTICLE